Detection of progression from cognitively unimpaired to mild cognitive 


   Note: An Official Proposal has not been Submitted to NACC.


   Lead Investigator:    Gary Chan
   Institution      :     
   E-Mail           :    kcgchan@uw.edu
   Proposal ID      :    1670



   Proposal Description:
   Conversion from cognitively unimpaired to mild cognitive impairment is a key  window to identify for clinical trials in order to target therapeutics for       dementia before clinical presentation of cognitive decline. We aim to (1)         compare longitudinal trajectories of UDS3 neuropsychological tests scores         between cognitively stable unimpaired participants and cognitive decliners, and  (2) determine the minimum number of subjects to enroll in a clinical trial to     have adequate power to deter minimal differences between cognitively unimpaired  and impaired participants.